diff --git a/srcpkgs/webkit2gtk/template b/srcpkgs/webkit2gtk/template
index df888b1c6d8..bb4d7ee8160 100644
--- a/srcpkgs/webkit2gtk/template
+++ b/srcpkgs/webkit2gtk/template
@@ -63,6 +63,14 @@ else
 	configure_args+=" --disable-x11-target"
 fi
 
+post_configure() {
+	if [ -n "$CROSS_BUILD" ]; then
+		# Fix -isystem issue for cross (See: https://bugs.webkit.org/show_bug.cgi?id=161697)
+		find -name flags.make -exec sed -i "{}" \
+			 -e "s;-isystem ${XBPS_CROSS_BASE}/usr/include ;;g" \;
+	fi
+}
+
 post_install() {
 	vlicense Source/WebKit/LICENSE
 }